Development of an Oxygenator for Long term Lung Assist.
スポンサーリンク
概要
- 論文の詳細を見る
This paper describes a membrane oxygenator for long term lung assist. A Membrane Oxygenator has been used for extracorporeal circulation as ECMO. However, the major oxygenators which have microporous membrane cause plasma leakage that deteriorates the performances for long term circulation. The authors developed a fine silicone hollow fiber which is twice the mechanical strength, low diameter and thin wall thickness. The fine silicone hollow fiber has almost the same transfer performance as microporous hollow fiber when it used in extracapillary flow type. However, extracapillary flow type which causes partial and accumulate flow easily has possibility of causing thrumbus and reduction of gas transfer performance. On the other hand, an intracapillary flow type oxygenator can make laminar flow in the hollow fibers. It is able to keep gas transfer performance stably for long term circulation without thrumbus. One of the disadvantages of intracapillary flow type is large pressure drop. Therefore, using softness of the silicone material, the authors designed and manufactured an oxygenator which has expanded inlet for decreasing pressure drop. This intracapillary oxygenator consists of25000silicone hollow fibers with a length of8cm inserted in the housing. The surface area of the membrane is3.0m 2. The priming volume is390mL. Gas transfer performance of the oxygenator was evaluated by in vitro experiments. Oxygen and carbon dioxide transfer rate were 52mL/min and95mL/miri, and pressure drop was30mmHg at a blood flow rate1L/min. The oxygenator developed in this study can be used for extended duration in such application as extracorporeal membrane oxygenator.
- ライフサポート学会の論文
ライフサポート学会 | 論文
- 細胞把持回転観察システムの開発とこれを用いた細胞内微細構造の3次元構造観察
- 温度応答性パターン化培養皿の調製と高機能性パターン化共培養細胞シートの構築
- 左右輪のトルクバランスによるパワーアシスト車いすの直進・旋回走行制御
- Evaluation of Mechanical Seals for Rotary Blood Pumps by a Chronic Animal Experiment
- 機能性高分子を修飾した高機能表面を用いたHPLC充填剤の開発