Relationship between wheezers and lung function tests in preschool children

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Asthmatic symptoms are already present during the infantile period, but diagnosis of asthma in the early stage of life is not easy.It has been suggested that there are some phenotypes in infantile recurrent wheezers.This study is an epidemiological survey of wheezers and asthma in preschool children in one village in Gunma Prefecture, Japan, from 2001 to 2007.A questionnaire based on ATS-DLD was completed by all of the parents, and lung function tests including bronchial hyperresponsiveness measurement using methacholine inhalation challenge were performed on the subjects who agreed to participate in our trial.Among 587 subjects, wheezers constituted 21 .8% (n=128), and diagnosed asthma constituted 10.4% (n=61).The value of Dmin in the wheezers without asthma group was significantly lower than that of the control group (p<0.001), but not with that of the asthma group (p>0.1).There was no significant difference in pulmonary function tests or in Dmin between with or without parental smoking, pet breeding and air pollution.We concluded that a half of infantile wheezers in preschool children were asthmatic, and they were not diagnosed by lung function tests or bronchial hyperresponsiveness measurement.
日本小児呼吸器疾患学会の論文