PZAを加えた小児肺結核6ヶ月治療成績

概要

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The initial phase of 6-month regemen of chemotherapy of pulmonary tuberculosis in children in this study consists of at least 2-month period of daily isoniazid, rifanpicin and pyrazinamide. The continuation phase is daily isoniazid and rifampicin for a further 4-months. Twenty-seven children with tuberculosis under 17 yr. of age were treated with this regemen from January 1992. Twenty-one of 27 cases had cured without relapse or side effects by this regemen. Six of 27 patients could not completed this regemen, because of side effects in two cases, abnormal liver function tests without jaundice caused by rifampicin and pyrazinamide respectively, drug resistance in two, cessation of treatment in one, and change to other clinics in one. 6-month regemen of chemotherapy of pulmonary tuberculosis in this study appeared to be effective and safe.
日本小児呼吸器疾患学会の論文