Synthesis of oligoinosinates with 2'-5' internucleotide linkage in aqueous solution using Pb2+ ion.

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概要

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• Oligoinosinates up to a pentamer were synthesized by the polymerization of inosine-5′-phosphorimidazolide in aqueous solution using Pb<SUP>2+</SUP> ion. 2′–5′ Internucleotide linkage was preferentially formed. The yields of the 2′–5′ linked dimer, trimer, and tetramer were 14.8, 4.5, and 1.6%, respectively. A small amount of linkage isomers of oligoinosinates with 3′–5′ linkage was obtained. The products were characterized by sequential enzyme tests.

• 公益社団法人 日本化学会の論文

著者

• OHNO Masaji

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Sawai Hiroaki

  Faculty of Pharmaceutical Sciences, University of Tokyo Hongo

関連論文

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• Preparation and properties of oligocytidylates with 2'-5' internucleotide linkage.
• Synthesis of oligoinosinates with 2'-5' internucleotide linkage in aqueous solution using Pb2+ ion.

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