The copper-catalyzed autoxidation of cysteine. The amount of hydrogen peroxide produced under various conditions and the stoichiometry of the reaction.
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概要
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Hydrogen peroxide is shown to be produced as an intermediate from oxygen in the copper-catalyzed autoxidation of cysteine. The amounts of cysteine oxidized and of hydrogen peroxide formed varied depending on the reaction conditions employed. The perpxide upon forming was spontaneously utilized for the oxidation of cysteine. As a result, the ratio of the concentration of hydrogen peroxide formed to cysteine oxidized is variable depending on the conditions. But, in dilute solutions, where the oxidation by the peroxide was slow, a stiochiometric relation of 2:1 was obtained between cysteine consumed and hydrogen peroxide produced. The rate of autoxidation is dependent on the concentration of oxygen dissolved. The double reciprocal plot of the rate against the concentration of oxygen gives a straight line, which indicates a possibility of the Michaelis-Menten type mechanism concerning the reoxidation or oxygenation of Cu(I) species.
- 公益社団法人 日本化学会の論文
著者
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HANAKI AKIRA
National Institute of Radiological Sciences
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Kamide Hiroko
National Institute of Radiological Sciences
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- The copper-catalyzed autoxidation of cysteine. The amount of hydrogen peroxide produced under various conditions and the stoichiometry of the reaction.