Photoinduced molecular transformations. 114. An efficient synthesis of 5,7-dihydroxy-4-methylisobenzofuran-1(3H)-one, a metabolite of aspergillus flavus and a key intermediate in the synthesis of mycophenolic acid.

スポンサーリンク

概要

• 論文の詳細を見る

• An efficient new synthesis of 5,7-dihydroxy-4-methylisobenzofuran-1(3<I>H</I>)-one, a metabolite of <I>aspergillus flavus</I> and a key intermediate in the synthesis of mycophenolic acid, is reported. The new synthesis involves the preparation of 1,2-dihydro-4,6-dimethoxy-3-methylbenzocyclobuten-1-ol and a regioselective β-scission of alkoxyl radical generated from it with lead tetraacetate as the key steps.

• 公益社団法人 日本化学会の論文

著者

• Suginome Hiroshi

  Organic Synthesis Division, Department of Chemical Process Engineering, Faculty of Engineering, Hokkaido University

• Kobayashi Kazuhiro

  Organic Synthesis Division, Department of Chemical Process Engineering, Faculty of Engineering, Hokkaido University

• Kobayashi Kazuhiro

  Organic Synthesis Division, Faculty of Engineering, Hokkaido University

• Shimizu Hideki

  Organic Synthesis Division, Faculty of Engineering, Hokkaido University

• Itoh Masahito

  Organic Synthesis Division, Faculty of Engineering, Hokkaido University

関連論文

• Replacement of a carbonyl group of camphor by an oxygen atom. Synthesis of 1,7,7-trimethyl-2-oxabicyclo(2.2.1)heptane.
• Synthesis of some five- and six-membered oxasteroids of cholestane series by ring contraction and the mass spectrometric fragmentations of oxasteroids.
• Photo- and thermally-induced radical rearrangements of 6-methyl- and 4,4,6-trimethylcholest-5-en-3.BETA.-ol.
• A simple synthesis of (.+-.)-cis-(6-methyltetrahydro-2-pyranyl)acetic acid, a constituent of civet.
• Photoinduced molecular transformations. 114. An efficient synthesis of 5,7-dihydroxy-4-methylisobenzofuran-1(3H)-one, a metabolite of aspergillus flavus and a key intermediate in the synthesis of mycophenolic acid.

スポンサーリンク