Peptides. IV. Racemization Suppression by the Use of Ethyl 2-Hydroximino-2-cyanoacetate and Its Amide

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概要

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• Racemization suppression by the addition of ethyl 2-hydroximino-2-cyanoacetate (IIIa) or 2-hydroximino-2-cyanoacetamide (IIIb), during coupling stages in peptide synthesis, was studied. The effectiveness of IIIa was compared with these of known additives by the help of Bodanszky's test, which is a simple and accurate method for racemization detection.

• 公益社団法人 日本化学会の論文

著者

• Itoh Masumi

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

関連論文

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• Peptides. IV. Racemization Suppression by the Use of Ethyl 2-Hydroximino-2-cyanoacetate and Its Amide

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