Peptides. VII. Some sulfonates of strongly acidic N-hydroxy compounds as novel coupling reagents.

スポンサーリンク

概要

• 論文の詳細を見る

• Sulfonates of strongly acidic <I>N</I>-hydroxy compounds such as 6-chloro-1-(<I>p</I>-chlorophenylsulfonyloxy)benzotriazole have been found to be excellent coupling reagents for amide bond formation. Amides can be prepared through either an active ester or a mixed anhydride according to the chosen procedure. Several active esters and protected di- and tripeptides prepared are listed in the Tables. Racemization, possible side reactions, and reaction pathways of the amide bond formation have also been discussed.

• 公益社団法人 日本化学会の論文

著者

• Hagiwara Daijiro

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Notani Jiyoji

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Nojima Hiroshi

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Itoh Masumi

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Takai Kuniaki

  Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

関連論文

• The Crystal Structure of 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethy1-2-methylpyrrolidine Hydrobromide
• Peptides. VII. Some sulfonates of strongly acidic N-hydroxy compounds as novel coupling reagents.
• Peptides. VI. Some oxime carbonates as novel t-butoxycarbonylating reagents.
• Peptides. IV. Racemization Suppression by the Use of Ethyl 2-Hydroximino-2-cyanoacetate and Its Amide

スポンサーリンク