Selective Homogeneous Hydrogenation of 3-Oxo-1,4-diene Steroids. III. On the Formation of Saturated 5α-Ketone in the Hydrogenation Catalyzed by Dichlorotris(triphenylphosphine)ruthenium
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概要
- 論文の詳細を見る
Hydrogenation of 1,4-androstadiene-2,17-dione (<B>1</B>) with RuCl<SUB>2</SUB>(Ph<SUB>3</SUB>P)<SUB>3</SUB> gives some saturated 5α-ketone together with 4-androstene-3,17-dione (<B>2</B>). The ratio of <B>2</B> to the saturated ketone formed increases almost in proportion to hydrogen pressure. The rate dependence upon hydrogen pressure has been shown to be first-order for formation of <B>2</B> and zero-order for formation of the saturated ketone. A mechanism which involves a 1,5-hydride shift at an intermediate species is proposed for the stereoselective formation of the 5α-ketone.
- 公益社団法人 日本化学会の論文
著者
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Nishimura Shigeo
Department Of Applid Chemistry For Resources Tokyo University Of Agriculture And Technology
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Nishimura Shigeo
Department of Industrial Chemistry, Tokyo University of Agriculture and Technology
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Tsuneda Kiyoshi
Chemical Research Laboratory, Teikohu Hormone Manufacturing Co., Ltd.
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Ichino Tomio
Department of Industrial Chemistry, Tokyo University of Agriculture and Technology
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Akimoto Akira
Department of Industrial Chemistry, Tokyo University of Agriculture and Technology
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Mori Hiromu
Chemical Research Laboratory, Teikohu Hormone Manufacturing Co., Ltd.
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