Synthesis of protected peptide fragments related to porcine motilin.

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概要

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• Syntheses are described of three protected peptide fragments which correspond to positions 1–6, 7–11, and 12–22, respectively, of the entire amino acid sequence of porcine motilin, a gastric motoractivity-promoting polypeptide. Stable tosyl group was used for the protection of ε-amino group of lysine and guanidino group of arginine. These protected peptide fragments were mainly constructed in step wise manner using benzyloxycarbonyl amino acid by mixed anhydride method in the presence of <I>N</I>-hydroxysuccinimide. For preparation of the C-terminal undecapeptide, fragment condensation method was employed using two protected tripeptide azides. The protected peptides and intermediates could be readily purified by simple procedure.

• 公益社団法人 日本化学会の論文

著者

• Miyamoto Seiji

  The First Research Institute, Tokushima Factory, Otsuka Pharmaceutical Co., Ltd.

• Mihara Shigeru

  The First Research Institute, Tokushima Factory, Otsuka Pharmaceutical Co., Ltd.

• Shimizu Fumio

  The First Research Institute, Tokushima Factory, Otsuka Pharmaceutical Co., Ltd.

関連論文

• Synthesis of porcine motilin by fragment condensation using three protected peptide fragments.
• Synthesis of protected peptide fragments related to porcine motilin.

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