The "Critical Thickness" of Organic Thin Films:With a Criticism to Long Range Force Hypothesis of Rothen

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概要

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• By studying the reactions of protein with the aid of monolayer technique, Rothen found that antigen and antibody, and also enzyme and substrate molecules, can react in despite of being apparently separated by some inert screen.<BR>He assumed from these results, that the specific long range forces operate in immunologic and enzymatic reactions. We have found that similar phenomena occurred in the following systems: monolayer of hapten-conjugated protein as antigen and antibody directed specifically against the hapten, azo-ovalbumin and ovalbumin, and even cholestanol and digitonin. Therefore, it leaves some room for consideration to assume specific long range forces in immunologic and enzymatic reaction alone.<BR>Besides, we suggested that there was required an almost constant thickness (about 150 Å.) of barium stearate to inhibit completely the combination of antibody with antigen in transferred film, independent of the variety of the systems.<BR>We have also noticed, from the data of the contact angle towards water, those of surface potential and of static friction coefficient of stearic acid multilayers on glass or metal surface, that the multilayers of stearic acid must have a thickness over about 150 Å. (same as the result of antigen-antibody reaction) to interrupt the effect of underlying substance, regardless of the phenomena concerned.<BR>These facts appear to suggest the fragile nature of screen film which is thinner than the certain thickness which we call the "critical thickness." Such a thin film may conceivably be such as the net-work structure loose enough to permit the diffusion and the penetration of large molecules. Such a physical state of screen film may primarily be responsible for the results of the experiments of Rothen, Singer and the present authors.

• 社団法人 日本化学会の論文

著者

• Tachibana Taro

  Department Of Anatomy And Cell Biology Osaka University Medical School

• Fukuda Kiyoshige

  Department of Chemistry, Faculty of Science, the University of Tokyo

• Tachibana Taro

  Department of Chemistry, Faculty of Science, the University of Tokyo

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