BETA ADRENERGIC RECEPTOR OF RABBIT THORACIC AORTA IN RELATION TO AGE
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概要
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Isolated aortic strips from rabbits older than 6 months (1.7-2.5 kg) when subjected to contraction by noradrenaline or adrenaline were relaxed by isoprenaline. The relaxation was not blocked by propranolol. When these strips were contracted by potassium chloride, isoprenaline produced a small relaxation which was sensitive to propranolol. In aortic strips from rabbits 2-3 months old (0.75-0.95 kg), the contraction produced by noradrenaline or potassium chloride was relaxed by isoprenaline; isoprenaline was equally active against both stimulants. Propranolol antagonised the action of isoprenaline competitively, with a pA<SUB>2</SUB> value, 7.05. In strips from rabbits from a lower age group, the pA<SUB>2</SUB> values of phentolamine against isoprenaline and methoxamine contractions were 7.61 and 7.50 respectively. It is concluded that aortas of rabbits older than 6 months are almost devoid of <I>beta</I> adrenergic receptors whereas those of rabbits 2-3 months old contain both <I>alpha</I> and <I>beta</I> adrenergic receptors.
- 公益社団法人 日本薬理学会の論文
著者
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GULATI O.
Pharmacological Research Unit, Council of Scientific and Industrial Research and Department of Pharmacology, Medical College
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GULATI O.D.
Pharmacological Research Unit, Council of Scientific and Industrial Research, New Delhi and Department of Pharmacology, Medical College
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PARIKH H.
Pharmacological Research Unit, Council of Scientific and Industrial Research and Department of Pharmacology, Medical College
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METHEW B.
Pharmacological Research Unit, Council of Scientific and Industrial Research and Department of Pharmacology, Medical College
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KRISHNAMURTY V.
Pharmacological Research Unit, Council of Scientific and Industrial Research and Department of Pharmacology, Medical College
関連論文
- BETA ADRENERGIC RECEPTOR OF RABBIT THORACIC AORTA IN RELATION TO AGE
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