ANALYSIS OF MODE OF ACTION OF SOME NICOTINIC BLOCKING DRUGS

スポンサーリンク

概要

• 論文の詳細を見る

• Hexamethonium and tetraethylammonium (TEA) produced parallel shifts (equilibrium blockade) of nicotine and dimethylphenylpiperazinium dose-response curves at all dose levels on isolated rabbit and guinea pig ileum preparations, while mecamylamine, pempidine, chlorisondamine and pentolinium produced parallel shifts at lower doses and nonparallel shifts (nonequilibrium blockade) at higher dose levels. Hexamethonium and TEA protected against the nonequilibrium blockade by mecamylamine, pempidine, chlorisondamine and pentolinium. Dose ratios for the combination of hexamethonium with TEA, with chlorisondamine or with pentolinium were consistent with competitive type of blockade. Dose ratios for the combination of hexamethonium with mecamylamine or with pempidine were not consistent with the noncompetitive type of blockade. It is concluded, that hexamethonium and TEA act as equilibrium competitive ganglion blockers while mecamylamine, pempidine, chlorisondamine and pentolinium act as nonequilibrium competitive ganglion blockers.

• 公益社団法人 日本薬理学会の論文

著者

• GULATI O.D.

  Pharmacological Research Unit, Council of Scientific and Industrial Research, New Delhi and Department of Pharmacology, Medical College

• Sethi O.P.

  Regional Research Laboratory

関連論文

• BETA ADRENERGIC RECEPTOR OF RABBIT THORACIC AORTA IN RELATION TO AGE
• ANALYSIS OF MODE OF ACTION OF SOME NICOTINIC BLOCKING DRUGS

スポンサーリンク