Conditioned drug effects to d-amphetamine- and morphine-induced motor acceleration in mice: Experimental approach for placebo effect.
スポンサーリンク
概要
- 論文の詳細を見る
Ninety-two mice were divided into 2 groups and 2.5 mg/kg of d-amphetamine sulfate was given to one group, and 10 mg/kg of morphine hydrochloride to the other, at daily intervals. These two groups were then futher divided into flicking light-presented and non-presented groups. The acute effects of the drugs on the ambulatory activity of each mouse were observed for 180 min after the drug administration. The motor-accelerating effect of both drugs was progressively enhanced with repeated administration. After the drugs were administered 10 times, physiological saline was given subcutaneously to the mice and the motor-accelerating effect of the drugs could be observed for a short time, especially in the flicking light-presented groups. This effect disappeared after repeated administration of saline solution at daily intervals for 6 days. Thus, the motor-accelerating effect produced by saline is considered to have been elicited as the result of conditioning between the conditioned stimuli (flicking light and other environmental factors) and drug effects.
- 公益社団法人 日本薬理学会の論文
著者
-
OHASHI Kyoichi
Behavior Research Institute, School of Medicine, Gunma University
-
TADOKORO Sakutaro
Behavior Research Institute, School of Medicine, Gunma University
-
Tadokoro Sakutaro
Behavior Research Institute School Of Medicine Gunma University
-
Hayashi Tetsu
Behavior Research Institute School Of Medicine Gunma University
関連論文
- RAT STRAIN DIFFERENCES IN THE ACQUISITION OF CONDITIONED AVOIDANCE RESPONSES AND IN THE EFFECTS OF DIAZEPAM
- FULLY AUTOMATIC APPARATUS FOR MEASUREMENT OF BEHAVIORAL RHYTHM IN RATS
- CUMULATIVE EFFECTS OF PENFLURIDOL, A LONG-ACTING NEUROLEPTIC DRUG, AS ASSAYED BY ITS BEHAVIORAL ACTIONS
- EFFECTS OF THYROIDECTOMY ON AMPHETAMINE-INDUCED ACCELERATION OF LOCOMOTOR ACTIVITY IN MICE
- EFFECTS OF CENTRAL DEPRESSANTS ON ROTA-ROD AND TRACTION PERFORMANCES IN MICE
- ANALYTICAL STUDY OF ACQUISITION ON FREE-OPERANT AVOIDANCE RESPONSE FOR EVALUATION OF PSYCHOTROPIC DRUGS IN RATS
- 122. ENHANCEMENTS OF TOXICITY AND MOTOR ACCELERATION EFFECT FOLLOWING INTERMITTENT ADMINISTRATIONS OF d-AMPHETAMINE (The Third Meeting for the Study of Toxic Effect)
- ATTAINMENT AND STABILITY OF THE PERFORMANCE IN DIFFERENTIAL LOW RATE WATER REINFORCEMENT IN RATS
- Conditioned drug effects to d-amphetamine- and morphine-induced motor acceleration in mice: Experimental approach for placebo effect.
- Enhancement of ambulation-increasing effect produced by repeated administration of methamphetamine in rats and neurochemical changes in catecholaminergic neurons.
- Strain differences in the reverse tolerance to methamphetamine and changes in catecholaminergic neurons in mice.
- Enhancement of prolactin-secreting effect produced by repeated administration of haloperidol in the avoidance situation and dopamine neurons in rats.