Enhancement of prolactin-secreting effect produced by repeated administration of haloperidol in the avoidance situation and dopamine neurons in rats.
スポンサーリンク
概要
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Male Wistar strain rats subcutaneously administered haloperidol at the dose of 0.035 mg/kg at 3-4 days interval, 10 times, in the avoidance situation. Enhancement of the prolactin-secreting effect of haloperidol was observed when it was given in the home cages at the 10th day after termination of the repeated administration. In these animals, <SUP>3</SUP>H-spiperone binding sites in the pituitary significantly increased, while the DOPAC/DA ratio in the hypothalamus significantly decreased. The enhancement phenomenon may be produced by a decrease in the activity of dopamine neurons in the hypothalamus.
- 公益社団法人 日本薬理学会の論文
著者
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Tadokoro Sakutaro
Behavior Research Institute School Of Medicine Gunma University
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Hayashi Tetsu
Behavior Research Institute School Of Medicine Gunma University
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KIFUNE Akira
Behavioral Research Institute, Gunma University School of Medicine
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