正常成熟婦人の血中progesterone, 17α-OH-progesterone, estrone, 17β-estradiolおよびestriolの動態について:第2編 : 正常妊娠, 分娩および産褥期における各ステロイドの変動

スポンサーリンク

概要

• 論文の詳細を見る

• Plasma progesterone, 17α-OH-progesterone, estrone, 17β-estradiol and estriol in human normal pregnancy, labor and the puerperium were measured simultaneously with radioimmunoassay or competitive protein binding assay. The steroids were extracted from the sample plasma with diethyl ether, and were separated through two steps of sephadex LH-20 microcolumn chromatography prior to the assays. <BR>From the beginning to the 25th week of pregnancy, a gradual rise in the levels of plasma progesterone was noted, followed by a steep increase toward term with a level of 150-250 ng/ml at the end of gestation. <BR>The levels of 17α-OH-progesterone during the 7 th or 8 th week of pregnancy were 2-3 ng/ml, which was above the normal range in the luteal phase, followed by a gradual decrease during 15-25 weeks of gestation. Thereafter, an increase toward term was seen with a mean level of 6-10 ng/ml in the 40th week. <BR>From the beginning to the end of pregnancy, plasma levels of estrone, 17β-estradiol, and estriol increased from less than 0.5 ng/ml to 2-4 ng/ml, from 1-2.5 ng/ml to 6-10 ng/ml, and from less than 1 ng/ml to 6-10 ng/ml, respectively. <BR>The disappearance of steroids from maternal peripheral blood in the puerperium was rapid. The half time of progesterone, 17α-OH-progesterone, estrone, 17β-estradiol, and estriol were 72 min, 68 min, 27 min, 27 min, and 48 min, respectively. <BR>Analysis of the interrelation between several kinds of steroids in pregnancy, labor, and the puerperium with simultaneous microassays will contribute to the clarification of some important physiological and pathological aspects of feto-placental-maternal functions and steroidogenic functions of the corpus luteum in pregnancy

• 日本内分泌学会の論文

著者

• 杉並 洋

  京都大学医学部婦人科学産科学教室

関連論文

• In vitroヒト黄体機能検索法の超微形態学的検討
• ヒト初期妊娠黄体の progesterone 分泌に及ぼす HCG および prostaglandin F2αの作用
• 合成 LH-RH 投与によるラット血漿中 LH 及び FSH の動態ならびに下垂体電子顕微鏡像について
• ラット下垂体前葉における合成LH-RHの作用: Short time incubation における gonadotropins の分泌
• 正常成熟婦人の血中progesterone, 17α-OH-progesterone, estrone, 17β-estradiolおよびestriolの動態について
• 正常成熟婦人の血中progesterone, 17α-OH-progesterone, estrone, 17β-estradiolおよびestriolの動態について:第2編 : 正常妊娠, 分娩および産褥期における各ステロイドの変動

スポンサーリンク