出生直後の新生児のcortisolレベルの推移
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概要
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Although assessment of adrenocortical function at birth has been made by several investigators, the results obtained do not agree well with one another. Also, knowledge of the cortisol level during the postnatal period was scanty. The purpose of the present study is : 1) to assess cortisol levels in normal newborns at birth and to compare them with levels in distressed newborns ; 2) to investigate changes of plasma cortisol levels in normal babies during the first 2 hours following delivery.<BR>Cortisol was measured in maternal and cord plasma, as well as in normal newborn plasma by a competitive protein-binding radioassay. An assessment of the reproducibility and precision of the method is presented. In maternal plasma, the average cortisol concentration (32. 4 μg/dl) was 2. 4 times greater than in umbilical arterial plasma (13. 3 μg/dl). The correlation coefficients do not suggest a significant relationship between the maternal and umbilical venous cortisol concentrations which means poor placental transfer of cortisol.<BR>To determine whether distressed infants showed evidence of adrenal cortical hyperfunction as compared to normal babies, serum cortisol levels were measured in infants delivered by vacuum extraction or forceps. No difference was found in circulation cortisol levels between these groups. However, Gemzell observed a higher 17-hydroxycorticosteroids concentration in the infants delivered by low forceps than in normal infants. These results suggest that the ability of the neonatal adrenal cortex to respond in the face of perinatal stress is variable according to individuals.<BR>Cortisol concentrations from normal infants at 1/2, 1, 2, 6, 12, 24 hours after birth were measured. In spite of individual variations and the limited number of observations, it is apparent that the cortisol concentration fell after birth. The levels of cortisone obtained at 1 hour of age were about half the levels at birth and were maintained during the first day of life.
- 日本内分泌学会の論文
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関連論文
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