亜急性甲状腺炎における血清free thyroxine および free3, 5, 3′-triiodothyronine

概要

論文の詳細を見る
Serum absolute free thyroxine (AFT4) and triiodothyronine (AFT3) were studied in ten patients with subacute thyroiditis, whose total serum T4 levels were elevated, and these were compared with those of ten patients with untreated hyperthyroidism, whose total T4 were elevated to the identical level. The mean value of the basal metabolic rate (BMR) in patients with subacute thyroiditis was 16 ± 14.8% (mean ± SD) and was significantly (P<0.001) lower than that (48.7 ± 15.7%) in hyperthyroidism. Serum thyroxine binding globulin concentrations measured by RIA were normal and did not differ from those in hyperthyroidism. Percent free T4 (%FT4) and AFT4 were both elevated in subacute thyroiditis to a comparable degree to those in hyperthyroidism. Serum total T3, %FT3 and AFT3 were also all elevated, but both total T3 and AFT3 were significantly (P<0.05, P<0.05) lower than in hyperthyroidism. Therefore, both of the ratios of T4/T3 and AFT4/AFT3 were significantly (P<0.01, P<0.01) lower than they were in hyperthyroidism. These results indicate that the significantly lower BMR and milder manifestation of toxic symptoms in subacute thyroiditis than in hyperthyroidism might be explained by the high ratios of T4 /T3 and AFT4/AFT3 as well as the short duration of chemical hyperthyroidism.
日本内分泌学会の論文