自己免疫性甲状腺疾患における末梢血単核細胞サブポピュレーションに関する研究
スポンサーリンク
概要
- 論文の詳細を見る
To estimate abnormalities in humoral or cellular immunity that relate to the etiologies of Graves' disease (GD) and Hashimoto's thyroiditis (HT), peripheral mononuclear cell subpopulations were enumerated by an immunofluorescence technique using monoclonal antibodies. Also antithyrotropin receptor antibodies (thyrotropin-binding inhibitor immunoglobulin, TBII) were measured by the radioreceptor assay according to Smith's method; and antithyroglobulin antibodies (TGHA) and antithyroid microsomal antibodies (MCHA), by the tanned red cell hemagglutination technique. The data obtained were analyzed for the count of peripheral total white cells, lymphocytes and granulocytes, and to the level of serum free thyroxine (T<SUB>4</SUB>), free T<SUB>4</SUB> index (FT<SUB>4</SUB>I) and free triiodothyronine index (FT<SUB>3</SUB>I).<BR>Peripheral white cells tended to be decreased in some cases of GD and HT. The absolute count of lymphocytes was slightly increased in GD but did not change in HT. On granulocytes (neutrophils mainly), the absolute count was considerably decreased in hyperthyroid GD. In this disease, FT<SUB>3</SUB>I showed significantly positive correlations to the percentage and absolute count of peripheral lymphocytes, whereas FT<SUB>4</SUB>I revealed significantly negative correlations to the percentage and count of granulocytes. These facts indicate that lymphocytosis and granulocytopenia in GD might be ascribed partially to the direct effects of thyroid hormones.<BR>The percentage of peripheral OKT3-positive cells (common T lymphocytes) was significantly decreased in untreated cases of GD, showing negative correlations to FT<SUB>4</SUB>, FT<SUB>4</SUB>I and FT<SUB>3</SUB>I. The absolute count of OKT4-positive cells (inducer/helper T lymphocytes) was increased in untreated cases of GD and hyperthyroid and euthyroid cases receiving anti-thyroid drugs (ATD) for GD : But peripheral OKT8-positive cells (suppressor/killer T lymphocytes) was significantly decreased in HT. The percentage of peripheral OKT8-positive To estimate abnormalities in humoral or cellular immunity that relate to the etiologies of Graves' disease (GD) and Hashimoto's thyroiditis (HT), peripheral mononuclear cell subpopulations were enumerated by an immunofluorescence technique using monoclonal antibodies. Also antithyrotropin receptor antibodies (thyrotropin-binding inhibitor immunoglobulin, TBII) were measured by the radioreceptor assay according to Smith's method; and antithyroglobulin antibodies (TGHA) and antithyroid microsomal antibodies (MCHA), by the tanned red cell hemagglutination technique. The data obtained were analyzed for the count of peripheral total white cells, lymphocytes and granulocytes, and to the level of serum free thyroxine (T<SUB>4</SUB>), free T<SUB>4</SUB> index (FT<SUB>4</SUB> I) and free triiodothyronine index (FT<SUB>3</SUB> I).<BR>Peripheral white cells tended to be decreased in some cases of GD and HT. The absolute count of lymphocytes was slightly increased in GD but did not change in HT. On granulocytes (neutrophils mainly), the absolute count was considerably decreased in hyperthyroid GD. In this disease, FT<SUB>3</SUB>I showed significantly positive correlations to the percentage and absolute count of peripheral lymphocytes, whereas FT<SUB>4</SUB>I revealed significantly negative correlations to the percentage and count of granulocytes. These facts indicate that lymphocytosis and granulocytopenia in GD might be ascribed partially to the direct effects of thyroid hormones.<BR>The percentage of peripheral OKT3-positive cells (common T lymphocytes) was significantly decreased in untreated cases of GD, showing negative correlations to FT<SUB>4</SUB>, FT<SUB>4</SUB> I and FT<SUB>3</SUB> I. The absolute count of OKT4-positive cells (inducer/helper T lymphocytes) was increased in untreated cases of GD and hyperthyroid and euthyroid cases receiving anti-thyroid drugs (ATD) for GD : But peripheral OKT8-positive cells
- 一般社団法人 日本内分泌学会の論文
一般社団法人 日本内分泌学会 | 論文
- 性ホルモンと生体反応
- A Hexapeptide Angiotensin Antagonist, [Des-(Asp1, Arg2), Ile8]-Angiotensin II
- 甲状腺ホルモンの吸収に関する研究
- DISC ELECTROPHORETIC ANALYSIS OF GROWTH HORMONE AND PROLACTIN IN THE ANTERIOR PITUITARY OF MOUSE
- 機能性甲状腺結節 (Autonomous Functioning Thyroid Nodule) 及び周辺組織におけるヨード代謝