インターベンション治療後の血管再狭窄の抑制を目的としたバルーン形状の力学的解析

概要

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Neointimal hyperplasia is considered partly responsible for restenosis after treatment with interventional balloon catheters and endovascular stents. Mechanical stretch and transluminal pressure imposed on the vascular wall are considered to be major causes of injury of vascular endothelial cells and smooth muscle cells, and of the proliferation of endothelium that follows. From the biomechanical viewpoint, this study was aimed to optimize a balloon configuration that can reduce the level of stress imposed on the vascular wall. In the theoretical analysis, the vascular wall was assumed to be membranous, and the optimization was formulated by minimizing the average tension exerted on the vascular wall. To solve a differential equation to obtain optimal balloon configuration, Euler's variations and the indeterminate multiplier of Lagrange were used. The optimal balloon configuration was expressed as the shape of rotated cosine curves depending on the incremental volumetric modulus of the vascular lumen and the elastic and dimensional indices of the vascular wall. The average tension exerted on the vascular wall estimated for this optimized balloon was 15-30% less than that of the conventional balloon configuration. Thus, the present study suggests that an optimally designed stent is applicable clinically as a new interventional balloon catheter device.
日本バイオレオロジ-学会の論文