Monocarboxylate transporter and lactate metabolism
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概要
- 論文の詳細を見る
For many years, lactate was considered as a metabolic waste product, and a cause of fatigue during exercise. However, lactate is now known as a carbohydrate fuel source, shuttled between cells and tissues. The movement of lactate across the plasma membrane is facilitated by a family of monocarboxylate transporters (MCTs). Among 14 identified MCT isoforms, MCT1 and MCT4 are present in the plasma membranes of skeletal muscle and are suggested to be related to exercise performance. Reports have shown that exercise training increases both MCT1 and MCT4 in skeletal muscle. This review will discuss the role of lactate as a fuel and exercise training-induced changes in lactate metabolism. In addition, studies of Thoroughbred horses, as models of elite athletes, are introduced.
著者
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Hatta Hideo
Department Of Life Science University Of Tokyo
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Hoshino Daisuke
Department Of Cancer Cell Research Institute Of Medical Science University Of Tokyo
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Kitaoka Yu
Department of Sports Sciences, The University of Tokyo
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HOSHINO Daisuke
Department of Sports Sciences, The University of Tokyo
関連論文
- 1A-O-8 Expression of monocarboxylate transporter (MCT)1 and MCT4 in overloaded mouse plantaris muscle(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima))
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- High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells
- 1B-07 Effect of lactate ingestion on glycogen and lactate metabolism during exercise(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- P2-50 Testosterone increases MCT1 and MCT4, and lactate transport in muscle(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- P2-49 Effects of repeated caffeine ingestion on MCT protein during voluntary running training(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- P2-48 Effect of lactate ingestion before endurance exercise on glycogen and lactate metabolism deuring exercise(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- 2R04 Changes of MCT expression in muscle hypertrophy and atrophy
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- PGC-1α increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
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- High-intensity interval training increases the rate of mitochondrial fatty acid oxidation in rat skeletal muscle
- Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle
- Monocarboxylate transporter and lactate metabolism
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- Monocarboxylate transporter and lactate metabolism