脂質投与が妊娠個体の下垂体副腎系機能に及ぼす影響についての実験的研究:(第1報) 副腎機能についての推移

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Remarkable advances have been made in the recent studies of lipid metabolism by Kinsel et al., Ahrens et al., Oliver and other investigators. They have confirmed that the quantity of cholesterol in the blood decreases when vegetable fat is administered to patients with hypertension. It is therefore presumed that cholesterol, a precursor of steroids, may be readily influenced by the vegetable fat rich in essential fatty acids. Furthermore, the vegetable fat is supposed to have an effect on the adrenal, ovary, and other hormonal organs as well as on the level of cholesterol in the blood.<BR>In the present study, the changes of the pituitary-adrenal milieu following treatment with sesame oil, 0.2 g daily per 100 g body weight, for 10 consecutive days in pregnant and non-pregnant albino rats were compared with those of the controls to which no sesame oil was administered.<BR>As for the effects on the adrenal, the contents of lipid and ascorbic acid were measured. Cholesterol and ascorbic acid were found to increase in the rats treated with vegetable fat, and this was evident especially in the non-pregnant rats. Besides, the histological findings on these animals were consistent with the biochemical data mentioned above.<BR>The results obtained in the pregnant rats showed exactly the same tendency as those of the non-pregnant ones, but the variations were generally slight.
日本内分泌学会の論文