糖質コルチコイドの副腎皮質抑制効果に及ぼす蛋白同化ステロイド併用の影響
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A study was undertaken to determine whether or not anabolic steroids prevent the adrenocortical suppression by glucocorticoids when given in combination. The results, in summary, were as follows : <BR>1) Animal experiment : 19-NAPP (Durabolin) 5 mg. administered for 10 days in combination with dexamethasone 0.2 mg. in rats, prevented the adrenal atrophy which occurred when dexamethasone alone was given. Adrenal cortex of rats given both 19-NAPP and dexamethasone were essentially normal in size and histological appearence.<BR>2) Clinical experiment : The glucocorticoids converting equivalent amount of in prednisolone, more than mean 15 mg. per day for over three weeks were given. On anabolic steroids 50 mg. per week of 19-NADC (Deca-Durabolin), 25-50 mg. per week of 19-NAPP, or 30 mg. per day of oxymetholone (Anadrol) were given with glucocorticoids.<BR>In 9 patients treated with glucocorticoids alone (group A), response of plasma 17-OHCS levels to ACTH-Z 40 I.U. administration was markedly decreased. Contrary to this, in 10 patients treated with a combination of anabolic steroids and glucocorticoids (group B), the plasma 17-OHCS response to ACTH test was generally greater than the response in group A. In 4 cases of the group who had been administered with 19-NADC 50 mg. per week, the plasma 17-OHCS response showed results within normal range. The mean value of increase per cent of plasma 17-OHCS following ACTH-Z administration in group B was within the normal limit.<BR>From the above mentioned results, it was observed that a simultaneous application of anabolic steroids is effective to prevent the suppression of the adrenal cortex by glucocorticoids.
- 日本内分泌学会の論文
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- 糖質コルチコイドの副腎皮質抑制効果に及ぼす蛋白同化ステロイド併用の影響