合成ステロイド並びに天然ステロイドの蛋白結合と生体内動態の差異
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概要
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Steroid binding with serum protein, transport into tissues, metabolisum in the liver and excretion in urine were investigated using c<SUP>14</SUP>-labeled cortisol and paramethasone. The following results were obtained : <BR>1) As compared with natural steroids, paramethasone has a relatively lower binding capacity with plasma protein, but is transported into animal tissues at a higher rate.<BR>2) Only a relatively small amount of paramethasone is metabolized in the liver ; so, their formation and the excretion of paramethasone metabolites are observed in a smaller quantity than those of natural steroids. It is, therefore, considered that paramethasone remains a long time in active form in the body.
- 日本内分泌学会の論文