糖尿病奇形の予防に関する実験的研究

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Unpedigreed virgin white mice of the Watanabe colony bred in this laboratory for a year and a half were used as experimental animals. Eighty mg of alloxan per kg body weight was given intravenously to the test group as well as the control on the 11 th day of gestation. The test group was treated 7 times with 0.4 units of "lente insulin" at 12-hour intervals from 36 hours after the alloxan injection, up to the 15th day of gestation. The dose of insulin incured no risk of hypoglycemia in diabetic mice, but was not necessarily enough to lower the elevated blood sugar levels to normal, in about half of all instances. Pregnant mice of both groups were sacrificed on the 19th day post coitum, and fetuses were removed by laparotomy and examined for externally visible defects.<BR>No fetus with gross anomalies existed in 407 born to 40 successful pregnant mice in the test group. In the control group treated by alloxan alone, on the other hand, there were 9 pregnancies which had more than one malformed fetus out of 40 successful ones (22.5 per cent) and 25 fetuses with cleft palate out of 369 live-born (6.8 per cent). The term, "successful pregnancy", is regarded as a pregnant mother having more than one live fetus found at laparotomy on the 19th day of gestation.<BR>An increase of the body weight due to pregnancy was less in mothers with malformed fetuses than in those with normal fetuses ; this difference being statistically significant by means of the chi-square test with the probability level of 0.02, whereas no appreciable difference was found between blood sugar levels in the two categories of mothers.
一般社団法人日本内分泌学会の論文

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堀井欣一
新潟大学医学部衛生学教室

糖尿病奇形の予防に関する実験的研究

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