血清Phosphataseより観たAlloxan糖尿に関する研究
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概要
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I made the investigation of the supplementary experiment and the reformation, the estimation of phosphatase activity of Seligman et al ; and it was found that blood sugar and alkaline phosphatase activity in diabetic patientate closely correlated. Secondary, it was the influence of the endocrine organs in the alloxan diabetes of the rabbits was investigated. Results obtained were as follows : <BR>1) After alloxanization, the non-treatment group showed the specific fluctuation of 3 stages in blood sugar and alkaline phosphatase activity changes parallel as well. <BR>2) The bilateral thyroidectomized group showed a little fluctuation of blood sugar and alkaline phosphatase activity respectively, and the continuous hyperglycemic stage did not appear in this group especially. <BR>3) The bilateral adrenalectomized group did not show very clearly the initial stage in blood sugar, and immediately moved to the second stage, i.e., hypoglycemic stage and died by hypoglycemic shock within about 3 hrs. to 18 hrs.. But alkaline phosphatase activity was increased progressively. <BR>4) The fluctuation of alkaline phosphatase activity in the alloxanization after the administration of the cortisone in the large dosage showed opposite on the initial and the second stage from the small dosage. <BR>5) The castration group showed prolonged hypoglycemic stage and then the continuous hyperglycemic stage with increased alkaline phosphatase. <BR>6) It was perhaps due to adrenal function that the fluctuations of blood sugar and alkaline phosphatase were observed at the initial stages of alloxan diabetes.
- 一般社団法人 日本内分泌学会の論文