糖尿病諸療法時の尿中Steroid排泄量の動向
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概要
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As reported previously, hyperfunction of pituitary-adrenal system often exists in diabetics especially in aged diabetics and in severe cases with ketosis. Such hyperfunction may be expected to aggravate the metabolic abnormalities of diabetes mellitus. Therefore, influence of various types of treatment such as insulin, mesoxalate, BZ 55, D 860 and phenethyldiguanide upon the urinary excretion of steroid hormones (17-OHCS and 17-KS) was studied. The influence of testosterone treatment was also studied.<BR>1) In patients whose urine contains normal or less than normal amount of 17-OHCS, no appreciable change in the amount of steroid hormones was found following various types of treatment in spite of the decrease in urinary sugar.<BR>2) In patients showing increased excretion of 17-OHCS ;<BR>a) Treatment using mesoxalate, BZ 55 and D 860 caused no marked change in the urinary excretion of 17-OHCS.<BR>b) Phenethyldiguanide treatment caused marked decrease in the urinary excretion of 17-OHCS.<BR>c) In patients treated with insulin, the urinary excretion of 17-OHCS and 17-KS decreased markedly.<BR>d) In most cases treated with testosterone, urinary excretion of 17-OHCS decreased. However, in 2 cases, increase in the urinary excretion of steroid hormones and in urinary glucose was observed.
- 日本内分泌学会の論文