インシユリンI131の生体内に於ける態度とその意義及び二, 三蛋白ホルモンとの比較

概要

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The attitude and significance of insulin-I131 intravenously administered to rats were studied. (1) The insulin-I1311 prepared by the author's procedure showed the property quite similar to the insulin in its hypoglycemic activity, ultraviolet absorption pattern, degradation by insulinase and so on. (2) The insulin-I131 administered intravenously was concentrated in kidney, liver and muscle. These organs were infered to be the main sites of action of insulin. (3) The insulin-I131 and some low-molecular protein hormones were filtrated into the gromerular capsules and reabsorbed at the proximal convoluted tubules. The reabsorption velocity seems 4o be determined by the molecular weight of proteins, that is, the concentration of such hormones to the kidney cortex is subject to the size of their molecules. (4) The kidney cortex seems to play the most important role to catabolize or inactivate the insulin in the very peculiar manner. (5) Some discussions were made on the mode of action of insulin.
日本内分泌学会の論文