肝が血糖調節に演ずる役割と, それに及ぼす内分泌因子の効果に関する試験管内証明

概要

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The roles of liver, the main source of blood sugar, and some endocrine factors played in blood sugar homeostasis were studied in vitro experimentation. 1) Prior to the experimentation with rat liver slices, the optimal conditions were examined for the glucose output of the liver slices. 2) There was observed a definite concentration gradient between the intracellular and extracellular sugar concentration of the liver. The sugar's transport among inside and outside liver cells was so controlled as to maintain the concentration gradient. 3) The insulin seemed to increase the sugar's inflow, whereas the L-epinephrine, glucagon and thyroid hormone did the outflow. 4) The alloxan-diabetic liver slices were always at the state where the outflow of sugar was accelerated. 5) The liver slices' glucose output was promoted in the serum from normal fasted human subjects, while inhibited in the serum from a man with the glucose infused. 6) For the mentioned above, the elaboration and mechanism were discussed.
一般社団法人日本内分泌学会の論文