抗甲状腺剤の下垂体甲状腺系に及ぼす影響に関する組織学的研究

概要

論文の詳細を見る
In order to clarify the acting mechanism of antithyroid drugs the histological studies on the thyroid and anterior pituitary of rabbits were performed following the administration of methylthiouracil, 1-methyl-2-mercaptoimidazole or inorganic iodine. The following results were obtained.<BR>1. Methylthiouracil may directly suppress the function of the thyroid and secondarily stimulate the release of TSH from the anterior pituitary in vivo. The direct action of methylthiouracil to the anterior pituitary, however, is not completely proven.<BR>2. It may be deduced that 1-methyl-2-mercaptoimidazole suppresses not only the function of the thyroid, but also suppresses the release of TSH from the anterior pituitary.<BR>3. Inorganic iodine may be considered to suppress first the release of TSH from the anterior pituitary and secondarily suppress the function of the thyroid.
日本内分泌学会の論文