汎発性鞏皮症治療の一例

概要

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Since the concept of collagen disease was established by Klemperer and his associates in 1942, scleroderma diffusum has also been considered to be under that category. However, concerning the treatment of that disease many problem are yet remained. The authors had recently a 42 year-old female patient of scleroderma diffusum with stiffening of skin and pigmentation in the extremities. Since conceptions of occurence of this disease expressed up to this day and various methods of treatment were examined by the authors, and this patient could be observed for a long period, this report was presented. Methods of treatment are as follows; (1) Administration of Meticorten and Predonine. (2) Transplantation of the suprarental body and the hypophysis. (3) Administration of Hyaluronidase and Chondroitin sulfate. (4) Vitamines, especially C and D. (5) Penicillin. Now, under the present state that the chief symptom of this disease is that appeared mainly in the skin and there is found no symptom by which pathological conditions can be certainly grasped, objective estimation of treatment effects is extremely difficult. Moreover, observing the progress of this disease it can not be cured by only one treatment. Therefore, combined used of various methods is desirable. Also in our case above mentioned methods were all used and Meticorten, Hyaluronidase and Penicillin are thought to have been most effective.
日本内分泌学会の論文