「腎疾患者におけるステロイド代謝の研究」:特に17KS分劃について
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I inspected the Adrens Cortical Function and the sexal gland Function of the Renal Diseases. First practiced the fraction measurment of the 17KS in urine by the Chromatography. Second measured the Estrone Estradiol fraction by the Fluorometry as estrogen in urine. In addittion inspected variation of 17KS-fraction of the Nephrose Syndrome who was medicated several Hormones.<BR>Details of this inspectations.<BR>1) Measurment of urinary 17KS fraction was practiced by microscale elution chrcmatcgraphy. Itsclinical usefullnes was corfirmed through the examination of Hydrolysis method, solvent density and eluate by standard substance.<BR>2) There was no difference between the sexal gland fraction (IV V fraction) and the adrens fraction (VI VII fraction) on 17KS fraction measurment of healthy.<BR>3) There are no remarkable change on the Akute Rinal Diseases but on the Chronic Rinal disease many of them there are remarkable decrease of VI VII fraction or IV V fraction. On Nephrose Syndrome IV V and VI VII fraction are remarkably decreased.<BR>4) In course and variation of the Nephrose Syndrome and the 17KS fraction, III, IVV, VI VII fraction are increased with decreased of dropsy weight of body, decrease urine albumin and bloodplasma albumin figures improvement.<BR>5) There is increase of VI VII fraction by medicate ACTH to the Nephrose Syndrome.<BR>6) The Nephrose Syndrome (who are administrated with testosterone) metabolized a testosterone only about 1/2 compare to healthy persons.<BR>7) At the measurment of the Estone estradiol fraction in urine certified two peak in two healthywomens who was in praemenstral and ovulation but on the Nephrose Syndrome women there was no peak.<BR>8) The Nephrose Syndrome who had clinical effects increased VI VII fraction but no clinicaly effected decreased III, IV V, VI VII fraction.<BR>9) To Nephrose Syndrome medicate the Testosterone contonuously increased IV V fraction but more long time medicate Testosterone decreased VI VII fraction.<BR>As above mentioned on Renal Diseases especialy on the Nephrose Syndrome is observed decline of function of glucocorticoid and the adrens corticale androgen and observed abstruction of metobolism.Beside on the Sexal gland there are declin of function of androgen and Estrogen but the Sexal gland second in its importance.