実験的糖尿動物血清の鶏胎児体外培養組織の生育に及ぼす影響

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1. Alloxan, Dithizon and Oxin were injected to the rabbits which had discharged livers by CCl4 since ca. 1 month before the injection. Diabetes occured more steadly after the liver discharge than control group, and especially in alloxan and dithizon injected group, permanent diabetes occured in the highest degree. 2. a) The inhibition to the growth of cultured tissues was most manifest in the serum of alloxan injected group, dithizon next, and in the serum of oxin injected group and d.epancreaticomized diabetic dogs, growth inhibitions were more or less slighter. b) In each group, the growth inhibition was severest at the initial hyperglycemic phase and at the second hypoglycemic phase. At the early period of the permanent hyperglycemic phase, tissue injuries were slightest, and later the injuries became more manifest again. c) Among the tissues of chick-embryo, liver was most sensitive to the additioned blood-sera of experimental diabetic animals and always exhibited growth inhibition of various severity. 3. When the sera of the experimental diabetic animals inactivated by the heat or filtered by the chamberand filter and or absorbed by caorin, its controllable power were relatively reduced. This, remarkable at the inactivated serum by the heat, but nicht so remarkable at the serum filtered or absorbed. 4. No correlation was found between the severity of the tissue injuries and blood sugar levels of these experimental diabetic animals. Then, as the late Prof. Iisuka discussed, the diabetogenic"toxin"shall exist nicht related to hyperglycemia.
日本内分泌学会の論文

実験的糖尿動物血清の鶏胎児体外培養組織の生育に及ぼす影響

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