Nitroglycerin-induced Heterogeneous Subendocardial Myocardial Blood Flow Observed by Cardioscopy in Patients With Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
It is controversial as to whether or not nitroglycerin (NTG) increases subendocardial myocardial blood flow (SMBF), and if it does, whether arterial or venous blood flow is increased in patients with coronary artery disease. This study was performed to examine NTG-induced changes in SMBF.Changes in SMBF induced by NTG (200 μg, i.v.) were examined by cardioscopy in 58 left ventricular wall segments of 58 patients with coronary artery disease. NTG-induced red and purple endocardial colors were defined as increased arterial and venous SMBF, respectively. Endocardial color before NTG administration was classified into brown, light brown, pale and white. Endomyocardial biopsy of the observed portion and 201Tl scintigraphy were performed in 40 of these patients immediately after cardioscopy and several days after cardioscopy, respectively.Upon administration of NTG, SMBF increased in 48 of 58 wall segments; arterial SMBF in 34 and venous SMBF in 12 wall segments; arterial SMBF in all 24 brown to light brown segments; venous SMBF, arterial SMBF and no change in 12, 10 and 5 of pale segments, respectively; and no change in all 10 white wall segments. 201Tl-scintigraphy and endomyocardial biopsy revealed that brown, light brown, pale and white endocardial color represented no ischemia, mild ischemia, severe ischemia and fibrosis, respectively.NTG caused an increase in either arterial or venous SMBF depending on control endocardial color, wall motion and severity of coronary stenosis.
著者
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Uchida Yasumi
Japan Foundation for Cardiovascular Research
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Uchida Yasuto
Department Of Cardiology Chiba-kensei Hospital
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Maezawa Yoshiro
Department Of Clinical Cell Biology
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Shirai Seiichiro
Department Of Cardiology Funabashi-futawa Hospital
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Kanai Masahito
Department Of Cardiology Toho University Medical Center Sakura Hospital
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Sakurai Takeshi
Department Of Cardiology Toho University Medical Center Sakura Hospital
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Kanai Masahito
Department of Cardiology, Toho University Sakura Hospital
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Maezawa Yuko
Department of Clinical Cell Biology, Chiba University
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Tabata Tsuyoshi
Department of Clinical Physiology, Toho University Sakura Hospital
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Tabata Tsuyoshi
Department of Clinical Physiology, Toho University Medical Center Sakura Hospital
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Maezawa Yoshiro
Department of Clinical Cell Biology, Chiba University
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Uchida Yasuto
Department of Cardiology, Toho University Ohmori Hospital
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