Background Data for General Toxicology Parameters in RccHanTM:WIST Rats at 8, 10, 19 and 32 Weeks of Age
スポンサーリンク
概要
- 論文の詳細を見る
Recently, RccHanTM:WIST (Wistar Hannover) rats were introduced to toxicity studies in Japan. The present study was performed to obtain control data for general toxicological parameters as an aid for interpretation of results in toxicity studies using this strain of rats. Four test groups comprising of 25 male and 25 female RccHanTM:WIST rats were housed for 2, 4, 13 or 26 weeks from 6 weeks of age and observed and examined for clinical observation, body weight, food consumption, urinalysis, hematology, blood chemistry, organ weight, necropsy and/or histopathology. Ophthalmological examination was not conducted in this study, and the data in this report were obtained from an ongoing 104-week background study in RccHanTM:WIST rats. These data were compared with the historical control data of CD(SD) (Sprague-Dawley) and/or F344 (Fischer) rats. The body weights of RccHanTM:WIST rats were lower than those of CD(SD) rats and higher than those of F344 rats. The ophthalmological examination revealed a greater incidence of focal corneal opacity. Histopathology revealed focal mineralization of the cornea and Berlin blue-positive pigmentation in the epididymal interstitium as well as hepatocytes. Other than the above, some minor differences were found in urinalysis, hematology, blood chemistry and organ weights as compared with CD(SD) rats.
著者
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Hoshiya Toru
Gotemba Laboratoly Bozo Research Center
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Kusuoka Osamu
Gotemba Laboratory Bozo Research Center Inc.
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Hatayama Kazuhisa
Gotemba Lab. Bozo Research Center Inc.
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Okazaki Shuzo
Gotemba Lab. Bozo Research Center Inc.
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Mochizuki Masahiro
Gotemba Laboratory Bozo Research Center Inc.
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SUZUKI Saori
Gotemba Laboratory, Bozo Research Center Inc.
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Tamura Kazutoshi
Gotemba Laboratory Bozo Research Center Inc.
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Okamura Toshiya
Gotemba Laboratory Bozo Research Center Inc.
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Kobayashi Junichi
Gotemba Laboratory Bozo Research Center Inc.
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Ogawa Tatsuya
Gotemba Laboratory Bozo Research Center Inc.
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Tamura Kazutoshi
Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan
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Suzuki Saori
Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan
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Hatayama Kazuhisa
Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan
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Okazaki Shuzo
Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan
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Hoshiya Toru
Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan
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