Carbohydrate Mimetic Peptides as Research Reagent and Therapeutic
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概要
- 論文の詳細を見る
Although numerous carbohydrates play significant roles in mammalian cells, development of carbohydrate-based reagents and therapeutics are hampered by the technical difficulty of chemically synthesizing complex carbohydrate structures. Use of carbohydrate mimetic peptides circumvents this difficulty, as short peptide can be easily synthesized and modified. We as well as others identified carbohydrate mimetic peptides by screening peptide displaying phage library using anti-carbohydrate antibodies and lectins. This review introduces our experiences with I-peptide that was used for identification of new carbohydrate binding receptor expressed in the lung endothelial cells, and those with IF7 peptide that can be used as a therapeutic against malignant tumors.
- 公益社団法人 日本薬学会の論文
著者
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Sugihara Kazuhiro
Department Of Obstetrics And Gynecology Hamamatsu University School Of Medicine
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Hatakeyama Shingo
Department Of Urology Hirosaki University Graduate School Of Medicine
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Fukuda Michiko
Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute
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Hatakeyama Shingo
Department of Advanced Transplant and Regenerative Medicine, Graduate School of Medicine, Hirosaki University
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Sugihara Kazuhiro
Department of Gynecology and Obstetrics, School of Medicine, Hamamatsu University
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