Osthole Attenuates Focal Inflammatory Reaction Following Permanent Middle Cerebral Artery Occlusion in Rats

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概要

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• Osthole, a main active constituent from Cnidium monnieri (L.) CUSSON, has been considered therapeutic agent in the treatment of ischemic stroke. This study was designed to investigate the effect of osthole on permanent middle cerebral artery occlusion (MCAO) in rats. Osthole was administrated by gavage to the normal and the MCAO rats. Rats were assessed for neurological deficit after 24 h following MCAO, then their brains were evaluated to determine the infarct area, and the mRNA and protein levels of some inflammatory factors were detected. It was found that MCAO animals pre-treated with osthole for 7 d showed significant improvement in all neurological tests compared with vehicle-treated MCAO groups. In addition, there was a significant decrease in infarct volume 24 h after occlusion in animals pre-treated with osthole versus the vehicle-treated MCAO group. MCAO also dramatically caused some inflammatory factors increase. However, pretreatment with osthole restored the mRNA and protein levels of these factors, including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) of ischemic penumbra cortices, suggesting that osthole possessed the function of preventing brain against ischemic damage, while no significant difference was found in any of normal groups with or without osthole. The present study demonstrated that osthole may be a novel neuroprotective therapy in the treatment of focal ischemic stroke.

• 公益社団法人　日本薬学会の論文

著者

• Gong QiHai

  Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan Universit

• Wang Lina

  Department Of Urology First Affiliated Hospital Of Dalian Medical University

• Li Fei

  School of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

• Shi Jingshan

  School of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

• Wang Lina

  Department of Neurology, Second Hospital of Hebei Medical University

• Wang Lina

  Department of Pharmacology and the Key laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical College

• Wang LiNa

  Department of Neurology, Affiliated Xi' an No.9 Hospital, Medical School of Xi'an Jiaotong University

• Gong Qihai

  Department of Pharmacology and The Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical College

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• Osthole Attenuates Focal Inflammatory Reaction Following Permanent Middle Cerebral Artery Occlusion in Rats

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