Conserved DNA Sequences Discovered From Atrial Fibrillation Related Genes

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概要

• 論文の詳細を見る

• Many genes change their transcription in atrial fibrillation (AF) patients, which indicates the functional relationship of these genes with AF. Thus, identifying the over-represented motifs in the upstream region of these genes would shed light on the mechanism of this disease. We analyzed a set of microarray experiments, selected from genes whose expression was changed, and extracted their regulatory sequences from genome databases. In addition, we used a motif discovery algorithm to obtain frequent DNA motifs in these sequences. Representative motifs were selected and matched to known transcription factor binding sites by clustering analysis, and 3 putative motifs related to AF were finally identified.

著者

• Wang LiNa

  Department of Neurology, Affiliated Xi' an No.9 Hospital, Medical School of Xi'an Jiaotong University

• Wu XiaoMing

  Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University

• Wang XuanQi

  Department of Cardiology, Fourth People's Hospital of Shaanxi Province

• Zhang HuQin

  Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University

• Du JianQiang

  Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University

• Wu XiaoMing

  Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University

• Du JianQiang

  Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University

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