Development of Imaging Mass Spectrometry

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概要

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• We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, purification, and labeling procedures for biological tissue sections. The mass microscope provides clear images with regards to the distribution of hundreds of biomolecules in a single measurement, and also helps in determining the cellular profile of the biological system. In this review, we focus on some of the recent developments in clinical applications and describe how the mass microscope can be employed to assess pathomorphology and pharmacokinetics.

• 公益社団法人　日本薬学会の論文

著者

• Setou Mitsutoshi

  Department Of Bioscience And Biotechnology Tokyo Institute Of Technology

• Hayasaka Takahiro

  Department Of Molecular Anatomy Hamamatsu University School Of Medicine

• Saito Yusuke

  Department Of Applied Chemistry Waseda University

• Waki Michihiko

  Department of Cell Biology and Anatomy, School of Medicine, Hamamatsu University

• Hameed Saira

  Department of Cell Biology and Anatomy, School of Medicine, Hamamatsu University

• Setou Mitsutoshi

  Department of Cell Biology and Anatomy, School of Medicine, Hamamatsu University

• Hayasaka Takahiro

  Department of Cell Biology and Anatomy, School of Medicine, Hamamatsu University

• Saito Yusuke

  Department of Cell Biology and Anatomy, School of Medicine, Hamamatsu University

• Hayasaka Takahiro

  Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine

関連論文

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