Anti-apoptotic Function and Mechanism of Ginseng Saponins in Rattus Pancreatic β-Cells

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概要

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• Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced pancreatic β-cell apoptosis via inhibiting nitric oxide (NO) production and regulating apoptosis-related genes. Among these genes, Bax, Fas and Caspase-3 gene expressions were up-regulated by high glucose, whereas only Bax and Caspase-3 gene expression were elevated by cytokines. In these two stimuli-induced apoptotic cells, Rg1 down-regulated Fas gene expression, while Rb1 decreased Caspase-3 gene expression. As a conclusion, Fas signal pathway and mitochondria stress is mostly related to anti-diabetes function of ginsenoside Rg1, while Caspase-3 pathway is essential when Rb1 is present.

著者

• Zhou Zhiguang

  Diabetes Center, The Second Xiangya Hospital, Central South University

• Chen Fang

  Horticulture and Landscape College, Hunan Agricultural University

• Chen Yuewen

  Horticulture and Landscape College, Hunan Agricultural University

• Kang Xincong

  State Key Laboratory of Sub-health Intervention Technology, State Administration of Traditional Chinese Medicine

• Zhang Zhixu

  State Key Laboratory of Sub-health Intervention Technology, State Administration of Traditional Chinese Medicine

• Liu Dongbo

  Horticulture and Landscape College, Hunan Agricultural University

• Zhou Zhiguang

  Diabetes Centre (Institute of Metabolism and Endocrinology), Central South University

関連論文

• Quantitation of L-Arginine and Asymmetric Dimethylarginine in Human Plasma by LC-Selective Ion Mode-MS for Type 2 Diabetes Mellitus Study
• Anti-apoptotic Function and Mechanism of Ginseng Saponins in Rattus Pancreatic β-Cells

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