6'-Hydroxyoxosorbicillinol, a New Lipoxygenase Inhibitor and PGD2/LTB4 Release Suppressor from Penicillium sp.

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概要

• 論文の詳細を見る

• A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C14H16O6), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C14H16O5), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC50, 16 µM) than 2 (IC50, 150 µM), and also showed prostaglandin D2 (PGD2) and leucotriene B4 (LTB4) release suppression activity (IC50, 10 µM for PGD2 and 100 µM for LTB4).

著者

• Nishikawa Masazumi

  School Of Food Agricultural And Environmental Sciences Miyagi Univ. Jpn

• Komoda Toshikazu

  School Of Food Agricultural And Environmental Sciences Miyagi Univ.

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• 6'-Hydroxyoxosorbicillinol, a New Lipoxygenase Inhibitor and PGD2/LTB4 Release Suppressor from Penicillium sp.
• 6'-Hydroxyoxosorbicillinol, a New Lipoxygenase Inhibitor and PGD_2/LTB_4 Release Suppressor from Penicillium sp.

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