10T024A, a New Phenazine Derivative, as a Radical Scavenger and a Prostaglandin, Leukotriene Release Suppressor

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概要

• 論文の詳細を見る

• We identified a new radical scavenger, 10T024A (C15H12N2O4), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radical-scavenging activity with an ED50 of 125 μM. Moreover, it showed prostaglandin D2 (PGD2) and leukotriene B4 (LTB4) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC50: 8 μM and 10 μM respectively.

著者

• Komoda Toshikazu

  School Of Food Agricultural And Environmental Sciences Miyagi University

• Nishikawa Masazumi

  School Of Food Agricultural And Environmental Sciences Miyagi Univ. Jpn

• TAMIYA Yuta

  School of Food, Agricultural, and Environmental Sciences, Miyagi University

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