Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids from Valeriana jatamansi
スポンサーリンク
概要
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Two new iridoids, jatadoids A (1) and B (2), and two known compounds (3 and 4) were isolated from Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Compound 1 possessed an isovaleroxy group at the C-3 position that has previously been unreported in the class of iridoids. Four compounds were evaluated and compounds 1 and 3 showed moderate neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
著者
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Yamakuni Tohru
Graduate School Of Pharmaceutical Sciences Tohoku University
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Ohizumi Yasushi
Graduate School Of Pharmaceutical Sciences Tohoku University
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Guo Yuanqiang
College Of Pharmacy And Tianjin Key Laboratory Of Molecular Drug Research Nankai University
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Xu Jing
College Of Pharmacy And Tianjin Key Laboratory Of Molecular Drug Research Nankai University
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Guo Ping
College Of Pharmacy And Tianjin Key Laboratory Of Molecular Drug Research Nankai University
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LI Yushan
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
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Guo Ping
College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University
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