Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities
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概要
- 論文の詳細を見る
Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4′-O-[6″-feruloyl]-β-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 µM) and A-549 (12.16 µM), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC50 value of 16.77 µM.
著者
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Wang Yuan-Yuan
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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Lu Lu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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Chen Jian-Chao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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Nian Yin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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Qiu Ming-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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Li Yan
State Key Lab. Of Phytochemistry And Plant Resources In West China Kunming Inst. Of Botany Chinese A
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Qing Chen
Kunming Medical College
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Qing Chen
Kunming Medical Coll.
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Qiu Ming-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
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Nian Yin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
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Wang Yuan-Yuan
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
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