Cardioactive C19-Diterpenoid Alkaloids from the Lateral Roots of Aconitum carmichaeli "Fu Zi"

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概要

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• Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli. led to the isolation of 5 cardioactive C19-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15α-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C19-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10−9 mol/L. However, mesaconine has almost no effect on heart rate.

• 公益社団法人　日本薬学会の論文

著者

• Liang Xiao-xia

  Department Of Chemistry Of Medicinal Natural Products West China College Of Pharmacy

• Chen Dong-lin

  Department Of Chemistry Of Medicinal Natural Products And Key Laboratory Of Drug Targeting Of Educat

• Wang Xiao-liang

  Department Of Mechanical Engineering Nagoya Institute Of Technology

• Jian Xi-xian

  Department Of Chemistry Of Medicinal Natural Products And Key Laboratory Of Drug Targeting Of Educat

• Wang Feng-peng

  Department Of Chemistry Of Medicinal Natural Products And Key Laboratory Of Drug Targeting Of Educat

• Chen Qiao-hong

  Deparmtment Of Chemistry Of Medicinal Natural Products West China Coll. Of Pharmacy Sichuan Univ.

• Liu Xiu-Xiu

  Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University

• Cai Xiu-Feng

  Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University

• Chao Ruo-Bing

  Department of Medicinal Analysis, West China College of Pharmacy, Sichuan University

• Chen Dong-lin

  Deparmtment Of Chemistry Of Medicinal Natural Products West China Coll. Of Pharmacy Sichuan Univ.

• Wang Xiao-Liang

  Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences

• Chen Qiao-Hong

  Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University

• Wang Feng-Peng

  Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University

• Jian Xi-Xian

  Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University

• Chen Dong-Lin

  Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University

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