Two New Curine-Type Bisbenzylisoquinoline Alkaloids from the Roots of Cyclea wattii with Cytotoxic Activities
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概要
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Two new curine-type bisbenzylisoquinoline alkaloids, wattisines A (1) and B (2) along with three known alkaloids were isolated from the roots of Cyclea wattii. Their structures were established by interpretation of NMR and high-resolution electrospray ionization (ESI)-MS data. Absolute configuration of wattisines A and B were determined by single-crystal X-ray diffraction and circular dichroism (CD) spectra, respectively. In vitro, wattisine A (1) showed significant cytotoxic activities with IC50 value of 1.74 μM against HCT-8, and 7.29 μM against Bel-7402.
- 公益社団法人 日本薬学会の論文
著者
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Liu Xiao-yu
Department Of Chemistry Of Medicinal Natural Products West China College Of Pharmacy Sichuan Univers
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Wang Feng-peng
Department Of Chemistry Of Medicinal Natural Products West China Collese Of Pharmacy Sichuan Univers
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Wang Jian-Zhong
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan Unive
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Wang Feng-peng
Department Of Chemistry Of Medicinal Natural Products And Key Laboratory Of Drug Targeting Of Educat
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Wang Jian-Zhong
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
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Wang Feng-Peng
Deparmtment of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University
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