Development of New Methods in Organic Synthesis and Their Applications to the Synthesis of Biologically Interesting Natural Products

スポンサーリンク

概要

• 論文の詳細を見る

• 2,6-Dimethyl-9-Aryl-9-phosphabicyclo[3.3.1]nonanes (9-PBN and 9-NapBN) and the chiral diaminophosphine oxides (DIAPHOXs) derived from aspartic acid have been introduced as useful ligands and preligands, respectively, for transition metal-catalyzed asymmetric synthesis. anti-Selective asymmetric hydrogenation 
of α-amino-β-ketoesters using Ru-, Rh-, Ir-, and Ni-catalysts through dynamic kinetic resolution have been developed for the first time, producing efficiently important anti β-hydroxy-α-amino acids. The total synthesis of several biologically active natural products was achieved by use of the transition metal-catalyzed reaction using DIAPHOX, anti-selective asymmetric hydrogenation, and reactions developed by us. Synthesis of 
tangutorine, an antitumor indole alkaloid, has been enantioselectively achieved for the first time. Enantioselective synthesis of a martinelline chiral core was accomplished using the asymmetric tandem Michael–Aldol 
reaction as a key step developed by us. This synthesis represents the formal total synthesis of martinelline and martinellic acid. Papuamide B was synthesized through the elucidation of unknown stereostructures by using the anti-selective asymmetric hydrogenation and reactions developed by us.

• 公益社団法人　日本薬学会の論文

著者

• Hamada Yasumasa

  Graduate School Of Pharmaceutical Sciences Chiba University

関連論文

• A Short-Step Synthesis of (2S, 3R)-3-Hydroxy-3-methylproline, a Component of Polyoxypeptins, Using a Tandem Michael-Aldol Reaction and Optical Resolution
• Synthetic Studies on Polyoxypeptins
• Total Synthesis of Halipeptin D
• Catalytic anti-Selective Asymmetric Hydrogenation of α-Amino-β-Keto Esters through Dynamic Kinetic Resolution
• Synthetic Studies on Papuamide A
• Synthetic Study on Homophymine A, a potent anti-HIV cyclodepsipeptide
• Synthetic Studies on Papuamides, Anti-HIV Cyclodepsipeptides from a Marine Sponge
• Synthetic Studies on Papuamides, Marine Cyclodepsipeptides
• P-208 Total Synthesis of Halipeptin A, a potent anti-inflammatory cyclodepsipeptide
• Synthetic Studies on Halipeptins, Anti-Inflammatory Cyclodepsipeptides
• Development of New Methods in Organic Synthesis and Their Applications to the Synthesis of Biologically Interesting Natural Products
• Synthesis of Novel Bidentate P-Chiral Diaminophosphine Oxide Preligands: Application to Pd-Catalyzed Asymmetric Allylic Substitution Reactions

もっと見る 閉じる

スポンサーリンク