Catalytic anti-Selective Asymmetric Hydrogenation of α-Amino-β-Keto Esters through Dynamic Kinetic Resolution
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概要
- 論文の詳細を見る
Asymmetric hydrogenation of α-amino-β-keto esters using ruthenium (Ru), rhodium (Rh), and iridium (Ir)-chiral phosphine catalysts proceeds anti-selectively through dynamic kinetic resolution to afford anti-β-hydroxy-α-amino acids with high enantiomeric purity, which are important intermediates for the synthesis of medicines and natural products. The mechanistic investigation has revealed that the Ru-catalyzed asymmetric hydrogenation takes place through the hydrogenation of the double bond in the enol tautomer of the substrate and the Rh- and Ir-catalyzed asymmetric hydrogenations proceed through the reduction of the keto tautomer of the substrate.
- 社団法人 有機合成化学協会の論文
- 2008-11-01
著者
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HAMADA Yasumasa
Graduate School of Pharmaceutical Sciences, Chiba University
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Makino Kazuishi
Graduate School Of Pharmaceutical Sciences Chiba University
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Hamada Yasumasa
Graduate School Of Pharmaceutical Sciences Chiba University
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