Catecholthioether Derivatives: Preliminary Study of in-Vitro Antimicrobial and Antioxidant Activities

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概要

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• In this research, synthesis, antimicrobial and antioxidant activities of a series of catecholthioethers having benzoxazole and tetrazole moieties are described. Antimicrobial activity was evaluated by minimum inhibitory concentration (MIC) assay. The synthesized compounds were tested in vitro against three Gram-positive bacteria including Staphylococcus aureus (clinical isolated), Staphylococcus aureus ATCC 25922, Enterococcus faecium (clinical isolated), and two Gram-negative bacteria including Klebsiella pneumoniae (clinical isolated) and Pseudomonas aeruginosa 27853 and the yeast Candida albicans in comparison with control drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 4—256 μg/ml. This shows compounds having tetrazole moiety were the most active against Gram-negative strains, whereas compounds having benzoxazole moiety were more active against Gram-positive ones. Also both of them showed significant antifungal activity against Candida albicans and had lower activity than the compared control drugs (Sulfamethoxazole and Fluconazole). The antioxidant activity was assessed using two methods, including, 1,1-biphenyl-2-picrylhydrazyl (DPPH) radical scavenging, and reducing power assays. Some of the catecholthioether derivatives showed antioxidant activity more than Trolox and butylated hydroxyanisole (BHA) as reference antioxidants.

• 公益社団法人　日本薬学会の論文

著者

• Nematollahi Davood

  Faculty Of Chemistry Bu-ali Sina University

• Adibi Hadi

  Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences

• Rashidi Atefeh

  Students Research Committee, Kermanshah University of Medical Sciences

• Khodaei Mohammad

  Chemistry Department, Faculty of Chemistry and Nanoscience and Nanotechnology Research Center (NNRC), Razi University

• Alizadeh Abdolhamid

  Chemistry Department, Faculty of Chemistry and Nanoscience and Nanotechnology Research Center (NNRC), Razi University

• Majnooni Mohammad

  Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences

• Pakravan Narges

  Chemistry Department, Faculty of Chemistry and Nanoscience and Nanotechnology Research Center (NNRC), Razi University

• Abiri Ramin

  Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences

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• Catecholthioether Derivatives: Preliminary Study of in-Vitro Antimicrobial and Antioxidant Activities

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