人血漿cholinesteraseの筋弛緩薬に及ぼす基礎的および臨床的研究

概要

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Basic and clinical studies were performed on the effects of human plasma cholinesterase (pChE) preparation upon succinyl choline chloride (SCC) with dogs and surgical patients. The results revealed the following. 1. Six units/kg of pChE preparation elevated pChE activity of dogs significantly. 2. Six units/kg of pChE preparation significantly reduced and shortened the muscle relaxant effects of SCC in dogs. 3. Significant rise in pChE activity was noted in humans with 2, 4 and 8 units/kg of pChE preparation 4. Two units/kg of pChE preparation administered to humans once elevated pChE activity, which returned to the original level within 5 minutes, whereas 4 and 8 units/kg could maintain the activity level for more than 3 hours 5. The effect of SCC was distinctly reduced and shortened in humans by administration of 2, 4 and 8 units/kg of pChE preparation. 6. Unless the SCC, which had been previously administered several times, induced the state of phase II blocking, the effects of pChE preparation were not adversely affected 7. The pChE preparation did not show any specificity to species when administered to humans and dogs. 8. No side effect was seen by pChE preparation in the circulatory systems of humans or dogs. From the above-mentioned results, it could be assessed that positive efficacy could possibly be expected by pChE preparation against prolonged apnea with SCC or reduced pChE activity in humans.
昭和大学・昭和医学会の論文